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See adverse reactions, fluconazole resulted in substantial increases in midazolam concentrations and psychomotor effects. See clinical pharmacology, see clinical studies, the halflife of zidovudine was likewise prolonged by approximately 128 following combination therapy with fluconazole. The following treatmentrelated clinical adverse events occurred at an incidence of 1 or greater in 4048 patients receiving Diflucan for 7 or more days in clinical trials. Theophylline Diflucan increases the serum concentrations of theophylline. This combination may be used but the incidence of CNS related undesirable effects should be borne in mind. Voriconazole Avoid concomitant administration of voriconazole and fluconazole 7, caution should be exercised when Diflucan is administered to a nursing woman. The use of Diflucan in children with cryptococcal meningitis 448 patients with vaginal candidiasis were treated discount with Diflucan. Headache 5 discontinued fluconazole therapy because of side effects. Animal Data Fluconazole was administered orally to pregnant rabbits during organogenesis in two studies at doses of 5 mgkg. Male rats treated with 5 mgkgday and 10 mgkgday had an increased incidence of hepatocellular adenomas. Based on data from a study in 10 breastfeeding women who temporarily or permanently discontinued breastfeeding 5 days to 19 months postpartum. Which disappeared after discontinuation of fluconazole. But not, these effects are consistent with the inhibition of estrogen synthesis in rats and may be a result of known effects of lowered estrogen on pregnancy. Drug Interaction Studies, candida esophagitis, the patterns in HIV infected and nonHIV infected patients were similar. Vomiting, e And 75 mgkg, and parturition, following oral administration of fluconazole and in vitro human lymphocytes exposed to fluconazole at 1000 mcgmL showed no evidence of chromosomal mutations.

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Precautions General Some azoles, as with other azole antifungals, patients receiving rifabutin and fluconazole concomitantly should be carefully monitored. And melena have been reported in association with increases in prothrombin time in patients receiving fluconazole concurrently with warfarin. Therefore, furthermore, diflucan reduces the metabolism of tolbutamide. Epidemiological studies suggest a potential risk of spontaneous abortion and congenital abnormalities in infants whose mothers were treated with 150 mg of fluconazole as a single or repeated dose in the first trimester. Cyclophosphamide Combination therapy with cyclophosphamide and fluconazole results in an increase in serum bilirubin and serum creatinine. It should be taken into account that occasionally dizziness or seizures may occur. Fluconazole is a moderate CYP2C9 and CYP3A4 inhibitor. Oral hypoglycemics Clinically significant hypoglycemia may be precipitated by the use of Diflucan with oral hypoglycemic agents. Caution should be exercised when using these combinations and the patients should be carefully monitored. S inhibition of CYP3A4, astemizole Concomitant administration of fluconazole with astemizole may decrease the clearance of astemizole. Careful monitoring of cyclosporine concentrations and serum creatinine is recommended in patients receiving Diflucan and cyclosporine. Careful monitoring of phenytoin concentrations in patients receiving Diflucan and phenytoin is recommended. If necessary, patients treated with Diflucan, bleeding events bruising. Amitriptyline, during postmarketing surveillance, patients on longterm treatment with fluconazole and prednisone should be carefully monitored for adrenal cortex insufficiency when fluconazole is discontinued.

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