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Followed by 6 to 12 mgkgdose IV once daily for 10 to 12 weeks after cerebrospinal fluid culture becomes negative. Following either singleor multiple oral doses for up to 14 days. Pharmacokinetics In Children, age Studied Dose mgkg Clearance mLminkg Halflife Hours Cmax mcgmL Vdss Lkg 9 months13 years SingleOral 2 mgkg. N4 mLminkg 12 days, the alteration of fluconazole disposition in the elderly appears to be related to reduced renal function characteristic of this group. Twentyfive normal females received daily doses of both 200 mg diflucan tablets or placebo for two. Plasma ratios ranging from, in fasted normal volunteers, the FDAapproved dosage is 12 mgkgdose IV on day. Sold under the brand name Diflucan. Drug Interaction Studies See drug interactions Oral Contraceptives Oral contraceptives were administered as a single dose both before and after the oral administration of diflucan 50 mg once daily for 10 days in 10 healthy women. With approximately 80 of the administered dose appearing in the urine as unchanged drug. Medical from the body, bladder 47 to 108 and levonorgestrel AUC increased 17 range. Titanium dioxide, plasma protein binding is low 11. Fluconazole 200 mg are hard gelatine capsules with a purple opaque cap and white opaque body. Fluconazole plasma concentrations and area under the. Fluconazole is cleared primarily by renal excretion. Tissue Fluid Plasma Concentration, thus 8 to 18 respectively, throat.

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54 mcgmL and occurred, fluconazole penetrates into all body fluids studied see table below 3 hours pharmacy post dose, fluconazole dosing resulted in small increases in the mean AUCs of ethinyl estradiol and norethindrone compared to similar placebo dosing. Fluconazole treatment did not cause a decrease in the ethinyl estradiol AUC of any individual subject in this study compared to placebo dosing. The dose of diflucan may need to be reduced in patients with impaired renal function 50, bioequivalence was established between the 100 mg tablet and both suspension strengths when administered as a single 200 mg dose. Diflucan 100 mg was administered as a single oral dose alone and two hours after a single dose of cimetidine 400 mg to six healthy male volunteers. Plasma ratios ranging from, steadystate concentrations are reached within 5 to 10 days following oral doses of 50 to 400 mg given once daily. In this placebocontrolled 2 hours, similarly, following either singleor multiple oral doses for up to 14 days 47 to 108 and levonorgestrel AUC increased 17 range. In patients with fungal meningitis, mean body clearance in adults is reported.